スポーツベッドアイオー

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Englishフリーワードで探す詳細検索はこちら検索研究者基本情報基本情報連絡先等研究専門分野学位所属学協会経歴研究活動情報論文書籍等出版物Joseph George ジョセフ ジョージ■所属部署名再生医療センター■職名特定教授  研究者基本情報基本情報https://www.josorge.com連絡先等[email protected]研究研究の概要:Molecular pathogenesis of hepatic fibrosis and hepatocellular carcinoma. Role of oxidative stress and current therapeutic approaches.専門分野消化器内科学学位医学博士生化学博士所属学協会2005年- Curr年American Association for Cancer Research, Membership # 1253802007年- Curr年American Association for the Study of Liver Diseases, Membership # 1113922019年- Curr年Asian Pacific Association for the Study of the Liver, Membership # MN-20822020年- Curr年Fellow of the American Association for the Study of Liver Diseases (FAASLD), Membership # 111392経歴2009年07月- 2010年08月Mount Sinai School of Medicine, New York; Division of Liver Diseases, Department of Medicine; 助教2014年06月- 2016年03月Mayo Clinic, Jacksonville, Florida, USA; Cancer Biology; 助教授研究活動情報論文Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis, Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George, British Journal of Pharmacology, 177:5195-5207, 2020年11月DOI:10.1111/bph.15258Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Journal of Molecular Medicine, 98:1203-1213, 2020年09月DOI:10.1007/s00109-020-01950-7Metabolism and interactions of antileprosy drugs, Joseph George, Biochemical Pharmacology, 177:113993, 2020年07月DOI:10.1016/j.bcp.2020.113993Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology, 863:172681, 2019年12月DOI:10.1016/j.ejphar.2019.172681Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis, Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Scientific Reports, 9:708, 2019年01月DOI:10.1038/s41598-018-37516-4Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Cell Death & Disease, 10:18, 2019年01月DOI:10.1038/s41419-018-1272-8Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry., Joseph George, Biological Chemistry, 399:499-509, 2018年DOI:10.1515/hsz-2017-0260Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice., George Joseph;Yan Irene K;Patel Tushar, Laboratory Investigation, 98:895-910, 2018年DOI:10.1038/s41374-018-0053-4MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, George, Joseph; Tsutsumi, Mikihiro; Tsuchishima, Mutsumi, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21:3821-3835, 2017年DOI:10.1111/jcmm.13304GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K. Tamura, N. Hayashi, J. George, M. Toshikuni, T. Arisawa, J. Hiratake, M. Tsuchishima, M. Tsutsumi, American Journal of Physiology: Gastrointestinal and Liver Physiology, 311:G305-G312, 2016年DOI:10.1152/ajpgi.00439.2015Noncoding RNA as therapeutic targets for hepatocellular carcinoma., Joseph George, Tushar Patel, Seminars in Liver Disease, 35:63-74, 2015年DOI:10.1055/s-0034-1397350Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y. Matsue, M. Tsutsumi, N. Hayashi, T. Saito, M. Tsuchishima, N. Toshikuni, T. Arisawa, J. George, PLoS One, 10:e0118744-e0118744, 2015年DOI:10.1371/journal.pone.0118744Serum endocan as a survival predictor for patients with liver cirrhosis, N. Toshikuni, K.Ozaki, J. George, M. Tsutsumi, Canadian Journal of Gastroenterology and Hepatology, 29:427-430, 2015年DOI:10.1155/2015/153805Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma, K. Ozaki, N. Toshikuni, J. George, T. Minato, Y. Matsue, T. Arisawa, M. Tsutsumi, Journal of Cancer, 5:221-230, 2014年DOI:10.7150/jca.7691Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T. Minato, M. Tsutsumi, M. Tsuchishima, N. Hayashi, T. Saito, Y. Matsue, N. Toshikuni, T. Arisawa, J. George, Molecular Medicine (Cambridge, Mass.), 20:490-502, 2014年DOI:10.2119/molmed.2014.00048Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease., N. Hayashi, J. George, M. Takeuchi, A. Fukumura, N. Toshikuni, T. Arisawa, M. Tsutsumi, PloS One, 8:e70034-e70034 (1-14), 2013年DOI:10.1371/journal.pone.0070034Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N. Hayashi, J. George, H. Shiroeda, T. Saito, N. Toshikuni, M. Tsuchishima, T. Arisawa, M. Tsutsumi, Journal of Gastroenterology and Hepatology, 28:1015-1018, 2013年DOI:10.1111/jgh.12137Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult., M. Tsuchishima, J. George, H. Shiroeda, T. Arisawa, T. Takegami, M. Tsutsumi, Digestive Diseases and Sciences, 58:1923-1933, 2013年DOI:10.1007/s10620-013-2574-4Osteopontin, an oxidant stress-sensitive cytokine,up-regulates collagen-I via integrin α(V) β(3) engagement and PI3K-pAkt-NFκB signaling., Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N., Hepatology, 55:594-608, 2012年DOI:10.1002/hep.24701Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches., Mormone E, George J, Nieto N., Chemico-Biological Interactions, 193:225-231, 2011年DOI:10.1016/j.cbi.2011.07.001Transgenic expression of human MMP-9 augments monocrotaline induced pulmonary arterial hypertension in mice., George J, D'Armiento J., Journal of Hypertension, 29:299-308, 2011年DOI:10.1097/HJH.0b013e328340a0e4Survivin knockdown and concurrent 4-HPR treatment attenuated human glioblastoma in vitro and in vivo., George J, Banik NL, Ray SK., Neuro-Oncology, 12:1088-1101, 2010年DOI:10.1093/neuonc/noq079Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines., George J, Banik NL, Ray SK., International Journal of Biochemistry and Cell Biology, 42:1164-1173, 2010年DOI:10.1016/j.biocel.2010.04.002Genistein induces receptor and mitochondrial pathways and increases apoptosis during Bcl-2 knockdown in human malignant neuroblastoma SK-N-DZ cells., George J, Banik NL, Ray SK., Journal of Neuroscience Research, 88:877-886, 2010年DOI:10.1002/jnr.22244Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma., George J, Banik NL, Ray SK., Clinical Cancer Research, 15:7186-7195, 2009年DOI:10.1158/1078-0432.CCR-09-1425Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth., George J, Banik NL, Ray SK., Journal of Cellular and Molecular Medicine, 13:4205-4218, 2009年DOI:10.1111/j.1582-4934.2008.00539.xBcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells, George J, Banik NL, Ray SK., Neurochemical Research, 34:66-78, 2009年DOI:10.1007/s11064-008-9659-zBiodegradable honeycomb collagen scaffold for dermal tissue engineering., George J, Onodera J, Miyata T., Journal of Biomedical Materials Research 2008; 87A (4): 1103-1111., 87A:1103-1111, 2008年DOI:10.1002/jbm.a.32277Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats., Joseph George, Biochemistry and Cell Biology, 86:235-243, 2008年DOI:10.1139/o08-038Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis., George J, Gondi CS, Dinh DH, Gujrati M, Rao JS., Clinical Cancer Research, 13:3507-3517, 2007年DOI:10.1158/1078-0432.CCR-06-3023siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Gene Therapy, 14:790-803, 2007年DOI:10.1038/sj.gt.3302929Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis., Joseph George, Clinical Biochemistry, 39:984-991, 2006年DOI:10.1016/j.clinbiochem.2006.07.002Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds., Joseph George, Yoshinori Kuboki, Teruo Miyata., Biotechnology and Bioengineering, 95:404-411, 2006年DOI:10.1002/bit.20939Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine induced esophageal carcinogenesis in rats., Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S., Journal of Gastroenterology and Hepatology, 21:805-813, 2006年DOI:10.1111/j.1440-1746.2005.04040.xSerum hyaluronan and hyaluronidase: very early markers of toxic liver injury., Joseph George, Robert Stern, Clinica Chimica Acta, 348:189-197, 2004年DOI:10.1016/j.cccn.2004.05.018Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Shujiro Takase, International Journal of Biochemistry and Cell Biology, 36:307-319, 2004年DOI:10.1016/S1357-2725(03)00253-XAscorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats., Joseph George, Clinica Chimica Acta, 335:39-47, 2003年DOI:10.1016/S0009-8981(03)00285-7Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen., George J, Rao KR, Stern R, Chandrakasan G., Toxicology, 156:129-138, 2001年DOI:10.1016/S0300-483X(00)00352-8Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine., George J, Chandrakasan G., Clinical Biochemistry, 33:563-570, 2000年DOI:10.1016/S0009-9120(00)00170-3Lactate dehydrogenase isoenzymes in dimethylnitrosamine induced hepatic fibrosis., George J, Chandrakasan G., Journal of Clinical Biochemistry and Nutrition, 22:51-62, 1997年DOI:10.3164/jcbn.22.51Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen., George J, Chandrakasan G., Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1292:215-222, 1996年DOI:10.1016/0167-4838(95)00202-2Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats., George J, Chandrakasan G., International Journal of Biochemistry and Cell Biology, 28:353-361, 1996年DOI:10.1016/1357-2725(95)00140-9Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats, Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchisihma, Mikihiro Tsutsumi, Molecular Medicine, 28: 143:s10020-022-00566-6, 2022年11月書籍等出版物Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies.Joseph George, Naren L. Banik, Swapan K. RayRay S.K. (Editor), Springer Science/Humana Press, New York, pp. 282-298, 2010年The Application of Atelocollagen Solution for Lacrimal Duct Occlusion.Lacrimal Gland, Tear Film and Dry Eye Syndromes 3: Basic Science and Clinical Relevance.Jun Onodera, Akihiko Saito, Joseph George, Toru Iwasaki, Hiroshi Ito, Yu Aso, Takashi Hamano, Atushi Kanai, Teruo Miyata, Yutaka NagaiKluwer Academic/Plenum Publishers, New York, pp. 1277-1281, 2002年※閲覧上の注意:直近1~2年の業績は毎年7~9月に担当委員会が実施する点検により、後日情報を修正することがありますのでご了承ください。Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.

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