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About Mission and Outline Background Activities For Community Message from Executive Director Toward the Development of Personalized Healthcare through the Promotion of Industry-Academia Collaboration Organization and Members Department of Community Medical Supports Department of Preventive Medicine and Epidemiology Department of Biobank Department of Integrative Genomics Department of Health Record Informatics Department of Education and Training Department of Public Relations and Planning General Affairs and Planning Sector Cohort Studies Sector Integrated Biobank Sector Integrated Omics Sector Group of Planning Group of Public Relations Group of Education and Training Group of Return of Genomic Results Center for Promotion of Cohort Studies Center for Health Survey Promotion Group of Brain Imaging and Research Group of Biobank Center for Biobank Utilization and Academia-Industry Partnership Group of Integrated Database Systems Group of Information Management for Genome-Cohort Study Group of Privacy Controls Group of Sequencing Group of Microarray-based Genotyping Group of Metabolomics Group of Metagenomics and Microbiome Group of Omics Data Analysis Center for Genome-Wide Association Study Office of Nihonbashi Branch Operation Center for Genome Platform Projects Policy Site Policy Social Media Policy Research Cohort Study and Biobank Community-Based Cohort Study (TMM CommCohort Study) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) Integrative Genomics Publications Facilities and Equipment Researchers Specimen and Data Collection Ethical Issues ToMMo's Library News Timeline sitemap links access & contact JAPANESE Large Small A A Top ResearchConstructing the First Version of the Japanese Reference Genome [Press Release] News Timeline all News Events Research Monthly archives 2024, April 2024, February 2024, January 2023, November 2023, October 2023, September 2023, August 2023, July 2023, June 2023, May 2023, April 2023, March 2023, January 2022, December 2022, November 2022, October 2022, September 2022, July 2022, May 2022, April 2022, January 2021, December 2021, November 2021, September 2021, August 2021, July 2021, June 2021, March 2021, January 2020, November 2020, October 2020, September 2020, August 2020, July 2020, June 2020, April 2020, March 2020, February 2020, January 2019, December 2019, November 2019, September 2019, August 2019, July 2019, May 2019, April 2019, March 2019, February 2019, January 2018, December 2018, November 2018, October 2018, September 2018, August 2018, July 2018, June 2018, May 2018, March 2018, February 2018, January 2017, December 2017, November 2017, October 2017, September 2017, August 2017, July 2017, June 2017, May 2017, March 2017, February 2017, January 2016, December 2016, November 2016, October 2016, September 2016, August 2016, July 2016, June 2016, May 2016, April 2016, March 2016, February 2016, January 2015, December 2015, November 2015, October 2015, September 2015, August 2015, July 2015, June 2015, May 2015, April 2015, March 2015, February 2015, January 2014, November 2014, October 2014, August 2014, July 2014, April 2014, March 2014, February 2014, January 2013, November 2013, August 2013, July 2013, June 2013, May 2013, April 2013, February 2013, January 2012, December 2012, November 2012, October 2012, September 2012, April 2012, March 2012, February Constructing the First Version of the Japanese Reference Genome [Press Release] Research: 2021/01/29 The Japanese now have their own reference genome thanks to researchers at Tohoku University Tohoku Medical Megabank Organization who completed and released the first Japanese reference genome (JG1). The study was published in the journal Nature Communications on January 11, 2021. “JG1 can aid with the clinical sequence analysis of Japanese individuals with rare diseases as it eliminates the genomic differences from the international reference genome,” said Jun Takayama, co-author of the study.  Back in 2003, the Human Genome Project, through a gargantuan global effort, cracked the code of life and mapped all the genes of the human genome. Since then, more accurate versions of the human reference genome have been realized. Aiding this has been the advancement in next-generation sequencing technologies that allow for short read of approximately several hundred bases in a massively parallel way, reducing the costs and time to sequence DNA and RNA. The international reference genome is based on an individual of African-European descent. This hampers investigating genetic variants or rare disease and cancer driving genes in Japanese owing to natural genomic difference reflective in different populations. Associate professor Takayama and professor Gen Tamiya from Tohoku University’s Tohoku Medical Megabank Organization (ToMMo) and the Advanced Research Center for Innovations in Next-Generation Medicine (INGEM) and colleagues from Tohoku University School of Medicine, School of Information Sciences, RIKEN AIP Center, and Miyagi Cancer Research Institute developed JG1 as the first part of the Japanese Reference Genome Assembly (JRGA) project. This high-precision reference sequence is applicable to the whole human genome analysis and was constructed by analyzing the genomes of three Japanese individuals using high-coverage, long-read next generation sequencing technologies. Researchers can efficiently investigate the causal genetic variants of rare diseases and cancer driver genes with JG1. “JG1 may be applicable to other populations, especially those from Asia. In addition, with the JG1, the accuracy of the Japanese allele frequency and haplotype reference panels gets improved,” added Takayama. Publication Details Title: Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference Authors: Jun Takayama, Shu Tadaka, Kenji Yano, Fumiki Katsuoka, Chinatsu Gocho, Takamitsu Funayama, Satoshi Makino, Yasunobu Okamura, Atsuo Kikuchi, Sachiyo Sugimoto, Junko Kawashima, Akihito Otsuki, Mika Sakurai-Yageta, Jun Yasuda, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto, and Gen Tamiya Journal: Nature Communications Published date: January 11, 2021 DOI: 10.1038/s41467-020-20146-8   *Updated version of Japanese reference genome(JG2) which is constructed by integrating six de novo phased assemblies from three Japanese male individuals is now available on jMorp.   Related Link 2020 major update of Japanese Multi Omics Reference Panel "jMorp": JG2 Japanese Reference Genome, 8.3KJPN allele frequency panel, and 25K Metabolome (2020.10.05) The Japanese reference genome, JG1, constructed by integrating three de novo assembled genomes of Japanese male individuals [Press Release] (2019.02.25) News Timeline Tweet About Mission and Outline Background Activities For Community Message from Executive Director Organization and Members Policy Research Cohort Study and Biobank Integrative Genomics Publications Facilities and Equipment Researchers Ethical Issues Specimen &#038; Data Collection ToMMo's Library News Timeline access & contact sitemap links JAPANESE Large Small A A Copyright(C) Tohoku University Tohoku Medical Megabank Organization All Rights Reserved. sitemap access & contact About Research Ethical Issues Specimen &#038; Data Collection ToMMo's Library News Timeline access & contact sitemap links Japanese

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